Solid-Phase Synthesis of a Combinatorial Array of 1,3-Bis(acylamino)-2-butanones, Inhibitors of the Cysteine Proteases Cathepsins K and L
- 22 April 1999
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Combinatorial Chemistry
- Vol. 1 (3) , 207-215
- https://doi.org/10.1021/cc9800374
Abstract
No abstract availableKeywords
This publication has 20 references indexed in Scilit:
- Use of X-ray Co-crystal Structures and Molecular Modeling To Design Potent and Selective Non-peptide Inhibitors of Cathepsin KJournal of the American Chemical Society, 1998
- Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells.Journal of Clinical Investigation, 1998
- Inhibition of apoptosis: potential clinical targetsEmerging Drugs, 1998
- Solid-phase parallel synthesis applied to lead optimization: Discovery of potent analogues of the GPIIb/IIIa antagonist RWJ-50042Bioorganic & Medicinal Chemistry Letters, 1996
- Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human OsteoclastsJournal of Biological Chemistry, 1996
- Generation and use of synthetic peptide combinatorial libraries for basic research and drug discoveryNature, 1991
- Regioselective Preparation of 4-Formyl-3,5-dimethoxyphenol, an Intermediate in the Synthesis of the PAL Solid-Phase Peptide Synthesis HandleSynthetic Communications, 1991
- Synthesis of an analog of tabtoxinine as a potential inhibitor of D-alanine:D-alanine ligase (ADP forming)Journal of Medicinal Chemistry, 1989
- Bromomethyl ketones and enolates: alternative products from ester homologation reactionsThe Journal of Organic Chemistry, 1985
- Direct, regiospecific 2-lithiation of pyridines and pyridine 1-oxides with in situ electrophilic trappingThe Journal of Organic Chemistry, 1983