THE GONADOTROPHIN RESISTANT OVARY SYNDROME: A CURABLE DISEASE?

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Abstract
A patient with the resistant ovary syndrome is reported. It is suggested that lack of synchronization between steroidogenesis in the granulosa and theca cells is responsible for the (acquired) occurrence of this syndrome. Feedback inhibition of pituitary gonadotropin secretion was achieved by exogenously administered ovarian steroid hormones [ethinyl-estradiol, medroxyprogesterone acetate]. All protein and steroid hormone levels returned to normal and spontaneous ovulatory cycles returned after withdrawal of medication. It is concluded that the so called resistant ovary syndrome is not an irreversible process.