Effects of indomethacin on the growth of cultured mammary tumors

Publisher Website
Google Scholar
Abstract
We have studied the relative prostaglandin E (PGE)' synthesizing abilities of a number of mammary tumor liners cultured in vitro. These lines differ in a number of biologic characteristics including tumorigenicity, immunogenicity and metastatic potential. They also synthesize different levels of PGE and these levels are in the same relative order seen in sit The metastatic tumor lines 4526 and 410.4 synthesize more PGE than does the non‐metastatic tumor line 410. Syntheticactivity of all lines decreases with time in culture. Relative synthetic capacity is not correseen with the slowest wowing (68H) and fastest growing (4526) cell lines. lndomethacin is able to inhibit the synthesis of PGE in vitro in a dose‐dependent manner and the presence of indomethacin in of cell division.