Inherited Medullary Thyroid Carcinoma: A Final Monoclonal Mutation in One of Multiple Clones of Susceptible Cells
- 27 January 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 199 (4327) , 429-431
- https://doi.org/10.1126/science.619463
Abstract
Inherited medullary thyroid carcinomas contain one form of glucose-6-phosphate dehydrogenase (G6PD) in black female patients who are mosaic in normal tissues for G6PD types A and B. The same individual may have several tumors each containing either G6PD A or G6PD B. The data suggest that the inherited defect is an initial mutation producing multiple clones of defective cells; each tumor then arises as a final mutation in one clone of these cells.This publication has 15 references indexed in Scilit:
- Clonal Origin of Inherited Medullary Thyroid Carcinoma and PheochromocytomaScience, 1976
- C-Cell Hyperplasia Preceding Medullary Thyroid CarcinomaNew England Journal of Medicine, 1973
- Histaminase activity: A biochemical marker for medullary carcinoma of the thyroidThe American Journal of Medicine, 1972
- Mutation and Cancer: Statistical Study of RetinoblastomaProceedings of the National Academy of Sciences, 1971
- Multiple Cell Origin of Hereditary NeurofibromasNew England Journal of Medicine, 1971
- Elevated Histaminase Activity in Medullary Carcinoma of the Thyroid GlandNew England Journal of Medicine, 1970
- THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPTJournal of Histochemistry & Cytochemistry, 1969
- Genetic Tests with a Sex-Linked Marker: Glucose-6-Phosphate DehydrogenaseCold Spring Harbor Symposia on Quantitative Biology, 1964
- Endocrine adenomatosis and peptic ulcer in a large kindredThe American Journal of Medicine, 1963