Inhibition by ricin of protein synthesis in vitro: 60S ribosomal subunit as the target of the toxin (Short Communication)
- 15 November 1973
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 136 (3) , 813-815
- https://doi.org/10.1042/bj1360813
Abstract
Poly(U)-directed polyphenylalanine synthesis by rat liver ribosomes is strongly inhibited by ricin. Experiments involving hybridization between subunits derived from normal and ricin-treated ribosomes demonstrate that the 60S subunit is the site of action of the toxin. The toxin inactivates the 60S subunit independently of the presence of the 40S subunit.Keywords
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