Tissue-Specific Suppression of Differentiation by 5-Bromodeoxyuridine In Vitro
- 1 May 1974
- journal article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 53 (3) , 509-515
- https://doi.org/10.1177/00220345740530030101
Abstract
Embryonic rat tooth germs were treated with 5-bromodeoxyuridine in vitro. Morphodifferentiation and histodifferentiation were arrested. Epithelial and mesenchymal deoxyribonucleic acid and protein synthesis were unaffected, whereas ribonucleic acid and collagen synthesis were retarded in the mesenchyme only. Inhibition of odontogenesis by this agent appears to be tissue-specific.Keywords
This publication has 8 references indexed in Scilit:
- Differential Response of Rat Tooth Germs to a Murine Sarcoma Virus in Cell Culture and Syngeneic Transplants2JNCI Journal of the National Cancer Institute, 1973
- Inhibition of cartilage development in organ cultures of chick somites by the thymidine analog, 5-bromo-2′-deoxyuridineDevelopmental Biology, 1972
- The Irreversible Inhibition of Differentiation of Limb-Bud Mesenchyme by BromodeoxyuridineProceedings of the National Academy of Sciences, 1972
- Inhibition of mucopolysaccharide synthesis by 5-bromodeoxyuridine in cultures of chick amnion cellsDevelopmental Biology, 1971
- Inhibition of Mammary Gland Differentiation in Vitro by 5-Bromo-2'-deoxyuridineJournal of Biological Chemistry, 1971
- The reversible control of animal cell differentiation by the thymidine analog, 5-bromodeoxyuridineExperimental Cell Research, 1970
- The uptake of nucleosides by cells in culture I. Inhibition by heterologous nucleosidesBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1969
- Cellular proliferation in the tooth germ of the rat incisorArchives of Oral Biology, 1965