ALPHA-GLOBIN GENE NUMBER - POPULATION AND RESTRICTION ENDONUCLEASE STUDIES
- 1 January 1980
- journal article
- research article
- Vol. 55 (4) , 706-708
Abstract
Restriction endonuclease analysis was used to test a proposed genetic model using .alpha.-globin gene number to account for the observed distributions of the proportions of HbS in sickle cell trait. In a subsample of specimens collected during a population survey in India, these studies confirmed that the postulated genotype was present in 22 of the 23 individuals examined. In the study population, the number of .alpha.-globin genes explains about 90% of the variance in the proportion of HbS in sickle cell trait (r2 = 0.895, P < 10-10).This publication has 9 references indexed in Scilit:
- Organization of the alpha-globin genes in the Chinese alpha-thalassemia syndromes.Journal of Clinical Investigation, 1979
- Sickle cell anemia as a syndrome: A review of diagnostic featuresAmerican Journal of Hematology, 1979
- Sickle cell anemia and trait in Southern India: Further studiesAmerican Journal of Hematology, 1979
- Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.Proceedings of the National Academy of Sciences, 1978
- Sickle cell anemia and trait in a population of southern indiaAmerican Journal of Hematology, 1977
- Trimodality in Tie Percentages of β Chain Variants in Heterozy-Gotes: The Effect of the Number of Aczive HBαStructural LociHemoglobin, 1977
- Variation in the Amount of Hemoglobin S in a Patient with Sickle Cell Trait and Megaloblastic AnemiaBlood, 1963
- FAMILIAL DIFFERENCES IN THE PROPORTION OF ABNORMAL HEMOGLOBIN PRESENT IN THE SICKLE CELL TRAIT 1Journal of Clinical Investigation, 1951
- RATIO OF SICKLE-CELL ANEMIA HEMOGLOBIN TO NORMAL HEMOGLOBIN IN SICKLEMICSJournal of Biological Chemistry, 1951