Indomethacin and the response to bumetanide

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Abstract
Pretreatment of 8 normal subjects with 100 mg indomethacin [prostaglandin synthetase inhibitor, IM] decreased the response to bumetanide [diuretic; BM]. Cumulative 4-h excretion of Na, due to 1.0 mg of BM, was reduced from 276 .+-. 22.9 to 202 .+-. 20.9 meq (P < 0.003). Effects on volume and Cl paralleled those on Na while K excretion was not affected. When response was analyzed as increment in fractional excretion over basal solute excretion determined from separate control studies, IM decreased response, an effect differing from that of IM on the response to furosemide [diuretic; FM]. The importance and mechanism of the difference in the effect of IM on BM and FM are not known.