PHENYLBUTAZONE-INDUCED DECREASE IN RENAL BLOOD-FLOW

  • 1 January 1978
    • journal article
    • research article
    • Vol. 204  (1) , 130-134
Abstract
Phenylbutazone (Butazolidin), an anti-inflammatory agent, was reported to decrease renal excretion of Na and water. Whether or not an alteration in renal hemodynamics could be involved in producing these effects was tested in anesthetized dogs. Renal blood flow (RBF) was monitored with electromagnetic flow probes. After i.v. administration of phenylbutazone 2 mg/kg, RBF fell by 20%. Glomerular filtration rate, Na and water excretion were also decreased and blood pressure increased slightly. The reduction of RBF and glomerular filtration rate by phenylbutazone indicates that a hemodynamic mechanism could be involved in the retention of Na and water induced by this agent. The decreased blood flow was correlated with a depressed renal secretion of prostaglandin E. In animals pretreated with indomethacin, another inhibitor of prostaglandin synthesis, administration of phenylbutazone did not result in any additional changes in renal hemodynamics or excretion of Na and water. Phenylbutazone antagonized the ability of furosemide to increase RBF, an inhibition which was previously shown to occur with indomethacin. Phenylbutazone appears to alter renal mechanisms in a manner similar to indomethacin.