EFFECT OF INDOMETHACIN ON RENAL-FUNCTION IN PENTOBARBITAL-ANESTHETIZED DOGS

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 198  (2) , 457-463
Abstract
The effects of indomethacin, an inhibitor of prostaglandin synthesis, on renal blood flow, glomerular filtration rate, urine flow and excretion of Na and K were studied in the anesthetized dog. Indomethacin, 2.5 mg/kg i.v., decreased renal blood flow but increased aortic pressure and calculated renal vascular resistance. Glomerular filtration rate was not influenced by the synthetase inhibitor. Na excretion was decreased, and p-aminohippurate extraction was increased after administration of indomethacin. Transient decreases in urine flow and K excretion were observed; however, both parameters returned to control value 75 min after administration of indomethacin. The early decrease in urine flow rate correlated closely with the decrease in Na excretion. In the anesthetized dog, endogenous prostaglandins may serve to maintain renal blood flow but not glomerular filtration rate. Under the conditions of the present experiments, Na excretion and to a lesser extent K excretion were suggested as being dependent on prostaglandin synthesis.