Increased plasma kallikrein activity and tumour growth suppression associated with intralesional bradykinin injections in hamsters

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Abstract
Daily intralesional injections of bradykinin (250 .mu.g) into syngeneic SV40 virus-induced fibrosarcomas in inbred hamsters for 21 days produced marked inhibition of tumor growth, marked lymphoid cell infiltration of tumors and significant elevations in plasma kallikrein and prekallikrein activity compared with intralesional saline injections. All tumors were of comparable size and growth rates before injections began. Plasma kallikrein levels of animals which received the standard tumor cell inoculum s.c. and did not develop tumors was elevated significantly above normal levels and above levels of animals with large tumors. Kallikrein inhibition activity of animals which did not develop tumors was depressed below normal levels. Intralesional injections of saline produced a significantly lesser response in plasma kallikrein and plasma prekallikrein activity than was encountered with s.c. saline injections in normal animals. Intralesional injections of bradykinin produced a response equivalent to that encountered with s.c. bradykinin injections in normal animals.