Miniaturization in functional genomics and proteomics
- 1 June 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 6 (6) , 465-476
- https://doi.org/10.1038/nrg1618
Abstract
Proteins are the key components of the cellular machinery responsible for processing changes that are ordered by genomic information. Analysis of most human proteins and nucleic acids is important in order to decode the complex networks that are likely to underlie many common diseases. Significant improvements in current technology are also required to dissect the regulatory processes in high-throughtput and with low cost. Miniaturization of biological assays is an important prerequisite to achieve these goals in the near future.Keywords
This publication has 132 references indexed in Scilit:
- Systems biology in drug discoveryNature Biotechnology, 2004
- The International HapMap ProjectNature, 2003
- Global analysis of protein localization in budding yeastNature, 2003
- Mass spectrometry-based proteomicsNature, 2003
- Comparative assessment of large-scale data sets of protein–protein interactionsNature, 2002
- Protein detection using proximity-dependent DNA ligation assaysNature Biotechnology, 2002
- Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometryNature, 2002
- Functional organization of the yeast proteome by systematic analysis of protein complexesNature, 2002
- Delineation of prognostic biomarkers in prostate cancerNature, 2001
- A novel genetic system to detect protein–protein interactionsNature, 1989