Deep Vein Thrombosis and Pulmonary Embolism in Congenital Factor VII Deficiency

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Abstract
HEREDITARY deficiency of factor VII was first described by Alexander et al. in 1951.1 Factor VII is necessary for the conversion of prothrombin into thrombin in the presence of tissue thromboplastin, and its deficiency is characterized by a prolonged Quick prothrombin time but normal tests of the intrinsic clotting system.2 3 4 It was initially thought that therapeutic anticoagulation with warfarin in the prevention and control of extension of red stasis thrombi was dependent upon achieving a Quick prothrombin time of 20 per cent control. This could often be achieved with high doses of drug on the first day, followed by a . . .