THE ANTITHROMBOTIC PROPERTIES OF COUMARIN DRUGS

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Abstract
Coagulation studies were performed on 28 patients who were receiving coumarin drugs for variable periods of time. These studies included the whole blood clotting times observed in siliconized tubes and the thromboplastin generation test, All patients with prolonged silicone clotting times had abnormal thromboplastin generation. No consistent relationship was found between the whole blood silicone clotting time and the prothrombin or factor VII levels. These studies indicated that factor DC and factor X deficiencies correlate directly with prolongation of the silicone clotting time in patients receiving coumarin drugs. Such deficiencies, rather than depressed prothrombin and factor VII levels, may be largely responsible for the antithrombotic activity of these drugs.