Rates of Transcapillary Movement of Calcium and Sodium and of Calcium Exchange by the Skeleton

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Abstract
The change in concn. of injd. radiocalcium in arterial blood plasma has been recorded in 8 dogs. In 2 of the dogs similar observations were made with simultaneously injd. radiosodium. Equations have been derived to descr. the time-concn. curves of the radioisotopes in the plasma. The equations allowed the calculation that the mean transcapillary migration rate of plasma Ca is 52% /min. and that the transcapillary migration rates of plasma Ca and Na are equal. The data were used, through the use of the isotope dilution equation, to calculate the apparent quantities of Ca and Na exchanged by bone at several times after injn. of the radio-isotopes. At 140 min. mean quantities of 93 mg. Ca and 8.2 g. Na had been exchanged by the skeleton of a 20-kg. dog. After 140 min. the skeleton continues to exchange Ca but not Na.

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