Differences in T-1824 and Cell Concentration of Venous Blood of Dogs After Dextran

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Abstract
In 42 expts. on 7 normal dogs, plasma vols. computed from hematocrit values were compared with dye dilution vols. computed from T-1824 concns. Differences were found after sampling alone, immediately after injn. of dextran soln., and after the appearance of vomiting and edema, which emphasize the unreliability of the usual hematocrit detns. as indices of plasma vol. changes. From dye dilutions it was confirmed that in normal dogs deictran in the dosage of 10 ml./kg. body wt. in 1/2 hr. expands the dye distribution vol./ by approx. 33% more than the vol. injd., and/by 50.33% of the injd. vol. at 3-4 hrs.