6-(Substituted methylene)penems, potent broad spectrum inhibitors of bacterial .BETA.-lactamase. II. Racemic furyl and thienyl derivatives.
- 1 January 1990
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 43 (1) , 76-82
- https://doi.org/10.7164/antibiotics.43.76
Abstract
A series of racemic 6-(substituted methylene)penems have been prepared. The compounds contain a 5-membered monoheteroaromatic ring at C-8. The antibacterial/synergistic and .beta.-lactamase inhibitory activities of both E- and Z-isomers and 2-substituted derivatives are compared.This publication has 2 references indexed in Scilit:
- 6-(Substituted methylene)penems, potent broad spectrum inhibitors of bacterial .BETA.-lactamase. I. Racemic 6-ethylidenepenems.The Journal of Antibiotics, 1990
- Synthesis and .BETA.-lactamase inhibitory activity of 9-(2-amidoethenylthio)-9-deoxy derivatives of clavulanic acid.The Journal of Antibiotics, 1988