Antigrowth effect of polyamine biosynthesis inhibitors on the dunning R 3327‐G prostatic tumor

1 January 1984

journal article
research article
Published by Wiley in The Prostate

Vol. 5 (4) , 439-444
https://doi.org/10.1002/pros.2990050408

Abstract

α‐Difluoromethylornithine (DFMO) and methylglyoxal‐bis‐guanylhydrazone (MGBG), when administered simultaneously, inhibited growth and were highly toxic to the Dunning R 3327‐G hormone‐resistant prostatic adenocarcinoma transplanted into Copenhagen rats. Neither DFMO (2%) nor MGBG at a nontoxic dose (15 mg/kg) inhibited tumor growth, but total (47% early cure rate) or near total suppression of growth of established tumors was observed in rats receiving both treatments.

Keywords

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