Increased Metabolic Rate without Thyroid Participation on Injection of Rats with Pituitary Erythropoietic Fractions.

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Abstract
Inasmuch as reports in the literature have indicated that increased activity of the bone marrow is accompanied by an elevated metabolic rate, the caloric output of rats injected with the pituitary erythropoietic fraction was examined. Rats used were females of the Long-Evans strain, hypophysectomized at 26-28 days of age and maintained for 45 days, during which time red cell volume decreased to a level half that of normal and the metabolic rate was decreased by about 50%. Erythropoietically active pituitary preparations increased the metabolic rate of hypophysectomized rats to normal levels, with little or no stimulation of the thyroids. A potent thyrotropic preparation was less effective in increasing the O2 consumption than was the erythropoietic factor. The erythropoietic factor also increased caloric output to normal levels in rats in which all functional thyroid tissue had been destroyed by radio-iodine.

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