Urinary Estrogen Titers in a Patient with Feminizing Adrenocortical Carcinoma

Abstract
The urinary estrogens in a patient with a feminizing adrenocortical tumor were partitioned and measured by gas chromatography. Marked elevations in the urinary titers, particularly of estriol, were observed. In addition to increased quantities of estriol, estradiol and estrone, high titers of 2-methoxyestrone, 16-hydroxyestrone, 16-ketoestradiol and 16-epiestriol were encountered. The significance of the urinary titers of estrogen in regard to the prognosis of feminizing adrenocortical tumors is discussed.