URINARY 17-KETOSTEROIDS AND ESTROGENS IN A CASE OF FEMINIZING ADRENAL TUMOR

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Abstract
Analysis of the urine for 17-ketosteroids and estrogens in a patient with a feminizing adrenal tumor revealed that etiocholanolone accounted postoperatively for over 90 per cent of the recognizable 17-KS. This, coupled with the virtual absence of androsterone and the increased excretion of estrogens, provides an explanation for the feminization that occurred in the face of high 17-KS production. Only 2 preoperative 24-hour specimens of urine were analyzed, but in them androsterone excretion was higher than it was postoperatively. Estrone constituted over 80 per cent of the recognizable estrogens. Estriol and 16-epiestriol occurred in small amounts, and estradiol-17B and equilenin were not detectable. It is suggested that "feminizing adrenal carcinoma" may not be a single entity.