Non-Random Centromere Division: a Mechanism of Non-Disjunction Causing Aneuploidy?

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Abstract
Early centromere separation was investigated in 12 normal children, 14 patients with Down''s syndrome and in 12 parents of children with autosomal trisomies. A significantly non-random centromere division of chromosomes was found in each of the cases. A higher frequency of early separated G chromosomes was observed in Down''s syndrome. In 2 mothers of trisomy-18 patients, the early division of chromosomes 18, generally seen in normal individuals, could not be demonstrated. The possible association between altered sequence of centromere division and non-disjunction needs further confirmation.

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