Progressive Multifocal Leukoencephalopathy

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Abstract
The radionuclide radiographic and pathologic findings in a patient with [viral] progressive multifocal leukoencephalopathy were correlated. Radionuclide imaging demonstrated the largest 2 of the many lesions observed at pathology. On repeated studies, 1 of the lesions developed a doughnut sign due to central necrosis. Cerebral angiography disclosed only 1 lesion which was initially suggestive of tumor encasement, but 4 wks later, this deteriorated into an avascular zone. There were no characteristic features of the lesions demonstrated by radionuclide imaging and cerebral angiography that could be specifically attributed to progressive multifocal leukoencephalopathy. [This patient had impaired immunity due to lymphosarcoma.].

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