Acid-base curve and alignment nomograms for swine blood

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Abstract
To construct acid-base curves and alignment nomograms for swine blood, known amounts of acid or base to aliquots of swine blood with 3 different concentrations of Hb were added. Pairs of blood samples were equilibrated at 2 different CO2 partial pressures and blood pH was measured. Data were analyzed by computer and mean values were created for complete data for 4 swine. Curve and alignment nomograms were constructed by computer. The resultant nomograms for swine blood differ from those constructed by Siggaard-Andersen for human blood, most importantly at base-excess values of +10 to +25 mmol/l. The possible reasons for the observed differencs are discussed and, although not completely resolved, may be related in large measure to the accuracy of pH determination and the methodology of nomogram construction.