Effect of myo-inositol on the glycerophospholipid composition of adult and fetal rat lung tissue

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Abstract
Myo-inositol was administered chronically to nonpregnant and to pregnant rats and the effect of this treatment on the glycerophospholipid composition of lung tissue and lung lavage was measured. In addition, the influence of myo-inositol administration to pregnant rats on the glycerophospholipid composition of lung tissue of their fetuses was investigated. The concentration of myo-inositol in adult and fetal blood was measured by gas-liquid chromatography of its trimethylsilyl derivative. For determination of glycerophospholipid composition, the total lipid extracts of lung tissues and lung lavage were separated by 2-dimensional TLC and quantified by lipid phosphorus assay of individual spots. Myo-inositol may be involved in the delayed appearance of PG (phosphatidylglycerol) in the lung surfactant of the human fetus in pregnancies complicated by diabetes mellitus. Patients with diabetes are known to have myo-inositol intolerance that is corrected by insulin therapy. Increased placental transfer of myo-inositol (from high maternal blood concentrations) and/or increased synthesis de novo by the fetus (supported by increased glucose availability) might result in a delay in the appearance of a lung surfactant enriched in PG.

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