Physiological factors influencing coronary blood volume in isolated dog hearts

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Abstract
Measurements of the weight and of the residual blood in an isolated, perfused heart permitted investigation of factors which influence coronary blood volume. Coronary blood volume was a near linear function of coronary arterial pressure between 30 and 125 mm Hg and was also linearly related to coronary flow in fresh preparations. For each 1 mm Hg change of mean coronary perfusion pressure, a corresponding change of the coronary blood volume occurred, amounting to about 100 mg blood/100 gm perfused heart. Decreases of contractile strength or heart rate caused reversible increases of the coronary blood volume.