A familial aggregation of pancreatic cancer. An in vitro study

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Abstract
In an attempt to clarify the etiology of pancreatic cancer, a family was studied in which 4 individuals manifested pancreatic cancer verified through 2 generations. Cell cultures from split-thickness skin biopsy specimens were obtained for 24 members from 3 generations (17 bloodline relatives, 7 family members by marriage) as well as 10 nonfamily normal subjects, none with a family history of solid tumors. One of the constant features of human monolayer dermal cultures was diploidy. Hyperdiploidy, other than tetraploidy, was rarely observed in cultures from normal subjects without a family history of solid tumors. Increased in vitro hyperdiploidy was seen in 8 of 17 family members studies.