Increased Susceptibility of Down's Syndrome Fibroblasts to Transformation by SV10.
- 1 April 1967
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 124 (4) , 1232-1236
- https://doi.org/10.3181/00379727-124-31974
Abstract
Tissue culture cell strains of foreskin fibroblasts obtained from 5 neonates with Down''s Syndrome (trisomy 21-22) were shown to be at least twice as susceptible and, on the average, 3 times as susceptible to transformation by the SV40 [Simian virus 40] virus as diploid foreskin fibroblasts from normal neonates. An even greater susceptibility to in vitro SV40 transformation was found in a strain of trisomy 18 fibroblasts. One reason for the increased incidence of neoplasia in Down''s Syndrome is a heightened intrinsic susceptibility of the trisomic cells to carcinogenic agents.This publication has 12 references indexed in Scilit:
- The limited in vitro lifetime of human diploid cell strainsPublished by Elsevier ,2004
- Chromosomal Alteration with Low Temperature Preservation of Tissue Fragments for Cultures.Experimental Biology and Medicine, 1966
- Susceptibility of Human Diploid Fibroblast Strains to Transformation by SV40 VirusScience, 1966
- Fanconi's AnemiaAnnals of Internal Medicine, 1966
- Genetic basis of cellular susceptibility to the Schmidt-Ruppin and Harris strains of Rous sarcoma virusVirology, 1966
- Chromosome Abnormalities in Constitutional Aplastic AnemiaNew England Journal of Medicine, 1966
- CHROMOSOMAL ANALYSIS OF LEUKOCYTE CELL LINES1966
- In vitro transformation of hamster and human cells with the adeno 7-SV 40 hybrid virus.Proceedings of the National Academy of Sciences, 1965
- Rapid transformation of human fibroblasts with low growth potential into established cell lines by SV40Journal of Cellular and Comparative Physiology, 1963
- The Mortality from Leukaemia and Other Cancers Among Patients with Down's Syndrome (Mongols) and Among their ParentsBritish Journal of Cancer, 1962