Fanconi's Anemia

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Abstract
Lymphocytes, fibroblasts, and bone marrow cells from patients with Fanconi''s anemia show an abnormally high frequency of chromosomal breaks and rearrangements. This susceptibility to chromosome breakage, which is inherited in an autosomal recessive pattern, may explain the clinical features of the syndrome: varied congenital malformations progressive bone marrow failure, and an extraordinary incidence of leukemias and solid tumors. Hematological relapses are often associated with clinical viral infections, suggesting that the chromosomal aberrations may be virus-induced.