HNK-1-DEFINED ANTIGEN DETECTED IN PARAFFIN-EMBEDDED NEUROECTODERM TUMORS AND THOSE DERIVED FROM CELLS OF THE AMINE PRECURSOR UPTAKE AND DECARBOXYLATION SYSTEM
- 1 January 1984
- journal article
- research article
- Vol. 44 (10) , 4432-4439
Abstract
The reactivity of the HNK-1 monoclonal antibody that, besides a subset of hematopoietic cells with natural killer activity, also detects neuroectodermal cells, was screened on 153 human tumors. Immunoperoxidase staining of paraffin sections revealed that HNK-1 detects neuroectoderm-derived cancers and tumors with endocrine activity. Because the antigen detected by HNK-1 is well conserved in paraffin sections, this antibody is of potential diagnostic value in routine histopathology and might help to elucidate the histogenesis of some poorly understood tumors.This publication has 22 references indexed in Scilit:
- Enolase isoenzyme distribution in the human brain and its tumoursThe Journal of Pathology, 1982
- S-100 PROTEIN IN SOFT-TISSUE TUMORS DERIVED FROM SCHWANN-CELLS AND MELANOCYTES1982
- Neurone specific enolase: an aid to the diagnosis of melanoma and neuroblastomaHistopathology, 1982
- A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).The Journal of Immunology, 1981
- Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.Journal of Histochemistry & Cytochemistry, 1981
- NEURON-SPECIFIC ENOLASE IS PRODUCED BY NEUROENDOCRINE TUMOURSThe Lancet, 1981
- HUMAN GLIOMA-ASSOCIATED ANTIGENS DETECTED BY MONOCLONAL-ANTIBODIES1981
- SPECIFIC IMMUNOREACTIVITY OF HYBRIDOMA-SECRETED MONOCLONAL ANTI-MELANOMA ANTIBODIES TO CULTURED-CELLS AND FRESHLY DERIVED HUMAN-CELLS1980
- Hybrid Myelomas Producing Antibodies Against a Human Neuroblastoma Antigen Present on Fetal BrainScience, 1979
- Brain Enolases as Specific Markers of Neuronal and Glial CellsScience, 1978