Acute Hemolytic Anemia in Primary Atypical Pneumonia Produced by Exposure and Chilling

Abstract
ACUTE hemolytic anemia in the course of primary atypical pneumonia has been reported by Dameshek,1 Finland2 and others. Elucidation of the mechanism of this form of anemia has not been offered. Clinical evidence shows that such anemia develops coincidentally with high titers of cold agglutinin in the serum. Since most of these reports have been concerned with patients to whom varying amounts of sulfonamides have been given and since acute hemolytic anemia can develop from the administration of the sulfonamides alone, it has been difficult to exclude the drugs entirely as the cause or to establish the acute hemolytic anemia . . .