Comparative in-vitro activity of moxalactam and cefotaxime against isolates from blood culture

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Abstract
The in vitro activity of moxalactam (LY-127935) was compared with that of cefotaxime (HR 756) and also with the activity of six cephalosporins and three aminoglycosides against clinical isolates recovered from blood cultures, including facultative Gram-negative bacilli, Staphylococcus aureus, coagulase-negative staphylococci and Streptococcus faecalis. There were 51 multiresistant strains of Grain-negative bacilli. Moxalactam was the least active of the study antibiotics against Staph. aureus and coagulase-negative staphylococci (with MIC90s of 8 mg/l and 32 mg/l, respectively). Cefotaxime was similar in activity as other cephalosporins against these organisms (MIC90s of 2 mg/l or less). None of the antibiotics was effective against Str. faecalis. Moxalactam and cefotaxime were the most active drugs for all Gram-negative bacilli recovered from blood cultures and comparable in activity. MIC90s of 0·5 mg/l or less were found for the Escherichia coli, Kiebsiella pneumoniae, Citrobacter spp., Serratia spp., Enterobacter spp., Proteus spp., Providencia stuartii and Salmonellae studied. Concentrations of 32 mg/l of moxalactam inhibited 90% of Pseudomonas spp. studied. Concentrations of cefotaxime of 16 mg/l or less inhibited 100% of the Pseudomonas spp.