The Uptake of Vitamin B12 by the Sediment of Jejunal Contents in Patients with the Blind-Loop Syndrome

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Abstract
Schjönsby, H. & Hofstad, T. The uptake of vitamin B12 by the sediment of jejunal contents in patients with the blind-loop syndrome. Scand. J. Gastroent. 1975, 10. 305-309. Following preincubation of intrinsic factor- (IF-) bound 57CoBi2 with the jejunal sediments of 6 patients with the blind-loop syndrome, the mean uptake by the sediments of IF-57CoB12 (28.1% ± 4.2% S.E.M.) was significantly higher than the mean uptake by jejunal sediments from 5 control patients (5.8% ± 3.5%) (p < 0.01). The uptake by the sediments significantly decreased when the incubations were carried out in the presence of lincomycin and neomycin. The jejunal sediments from the patients with the blind-loop syndrome inhibited the uptake of IF-57CoB12 by perfused rat intestinal segments (p < 0.01), whereas the sediments from the control patients had no such inhibitory effect (p > 0.5).