Synthesis of a Trifucosyl Ley Heptasaccharide Corresponding to a Tumor-Associated Glycolipid
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 11 (1) , 77-88
- https://doi.org/10.1080/07328309208016143
Abstract
The trifucosyl Ley derivative, 2-(p-trifluoracetamidophenyl)ethyl O-α-L-fucopyranosyl-(l→2)-O-β-D-galactopyranosyl-(l→4)-O-[α-L-fucopyranosyl-(1→3)]-O-2-acetamido-2-deoxy-β-D-glucopyranosyl-(l→3)-O-β-D-galactopyranosyl-(l→4)-O-[α-L-fucopyranosyl-(l→3)]-2-acetamido-2-deoxy-β-D-glucopyranoside, was synthesized from thioglycoside building blocks. A two plus three condensation gave a linear pentasaccharide derivative which was difucosylated and deprotected to give the target structure.Keywords
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