Chronology of the Gene
- 1 October 1971
- journal article
- research article
- Published by Cambridge University Press (CUP) in Acta geneticae medicae et gemellologiae
- Vol. 20 (4) , 323-349
- https://doi.org/10.1017/s1120962300011306
Abstract
Summary: The switching of genes from the silent to the operating condition following a rigorous temporal sequence may be called “chronology of the gene”. The succession of times and its biocybernetic mechanism are peculiar to each species, but the duration of information exhibits wide intraspecific variations between populations, families, and individuals. The highly isochronic behavior of MZ twins is proof of the existence of an individual temporal constitution.Our previous studies have proved that the duration of each information is a property of the corresponding genotype, depending on its potential time of activity (chronon), which depends in its turn on the same genotype's energy of stability (ergon).In terms of molecular genetics, the stability against mutation of each gene, governing its Ergon/Chronon (E/G) system, is a function of three factors:(1) Code degeneracy, i.e., the different stability of synonyms coding for the same information through different ratios of GC and AT bases, the former being the more stable.Keywords
This publication has 10 references indexed in Scilit:
- The Heredity of Biological Time and Population Genetics Diabetes, Lupus Erythematosus, and Peptic UlcerActa geneticae medicae et gemellologiae, 1970
- Biology of the Gene: The Ergon/Chronon SystemActa geneticae medicae et gemellologiae, 1969
- Chronon and the Problem of Anticipation (On two family cases of diabetes)Acta geneticae medicae et gemellologiae, 1967
- Endogenous Circadian Rhythm in Cytoplasm of Acetabularia : Influence of the NucleusScience, 1964
- The effects of actinomycin D and puromycin on morphogenesis in amphibian eggs and Acetabularia mediterraneaDevelopmental Biology, 1964
- Biochemistry of AgingScience, 1961
- General Theory of Mortality and AgingScience, 1960
- ON THE NATURE OF THE AGING PROCESSProceedings of the National Academy of Sciences, 1959
- THE PROBLEM OF ANTICIPATION IN PEDIGREES OF DYSTROPHIA MYOTONICAAnnals of Eugenics, 1947
- The Time of Action of Genes, and Its Bearing on some Evolutionary ProblemsThe American Naturalist, 1932