A Study in Dogs of Methods Suitable for Estimating the Rate of Myocardial Uptake of Rb86 in Man, and the Effect of 1-Norepinephrine and Pitressin® on Rb86 Uptake1

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Abstract
The rate of uptake of Rb86 by the dog myocardium can be estimated within 20% by monitoring externally over the heart. Infusion of 0.065 pressor units of Pitressin per kg per minute decreased Rb86 uptake by 40% and 2.5 [mu]g l-norepinephrine per kg per minute increased uptake 65%. These changes were in the same direction as the probable changes in coronary blood flow. Rb86 uptake was 45% faster in the left ventricle of control dogs than in the right ventricle and 15% faster in the inner portion on the right ventricle than in the outer portion. Minor differences in the uptake rate of the inner and outer portions of the left ventricle were greatly exaggerated by drugs.

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