Calcium-Dependent Aldosterone Secretion in Anephric and Nonnephrectomized Patients on Regular Hemodialysis*

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Abstract
The effect of a continuous Ca infusion on the plasma levels of aldosterone, renin activity and cortisol was studied in 6 anephric and 4 nonneprectomized patients on regular hemodialysis. In both groups, a significant increase in whole blood ionized Ca (b-Ca2+) was demonstrated. A significant increase in plasma aldosterone (PAC) was noted in the nonnephrectomized patients, in whom the rise in PAC correlated with the increase in b-Ca2+. However, in the anephric patients only a smaller and insignificant increase in PAC was found. No significant changes were demonstrated in plasma cortisol or renin activity, nor K or Na concentrations in either group. Ionized Ca influences the plasma levels of aldosterone in uremic patients on regular hemodialysis.