The Metabolism of Co-Ral (Bayer 21/199) by Tissues of the House Fly, Cattle Grub, Ox, Rat, and Mouse1

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Abstract
In mammals, the liver is primarily responsible for Co-ral metabolism. In the mouse, which is susceptible to Co-ral® (O,O- diethyl O-(3-chloro-4-methylumbelliferone) phosphorothionate) the compound is activated, and there are no degrading systems. In the ox and rat, which are resistant to Co-ral, the compound is degraded. It has been shown for the ox that both an activating and a degrading system are in the liver, but the latter is more potent. In the house fly (Musca domestica L.), and cattle grub (Hypoderma bovis (L.)), which are susceptible to Co-ral, there is : activating but no degrading system. Activation by the cattle grub is associated with fat body and gut. The results account for the selective toxicity of Co-ral, and possibly for the fact that only dermal treatment controls cattle grubs in the ox.