Effect of rat andβ-human interferons on hyperacute experimental allergic encephalomyelitis in rats
- 1 July 1985
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 16 (5) , 397-403
- https://doi.org/10.1007/bf01982879
Abstract
Human interferon-β (human IFN-β) and rat interferon (rat IFN) were evaluated on experimental allergic encephalomyelitis (EAE) in rats, a delayed cellular reaction resembling human multiple sclerosis (MS). Rat IFN was active by intravenous and intracerebroventricular routes. It decreased the severity of clinical symptoms of paralysis during the 22 days of the assay. Human IFN-β, on the contrary, had no effect when similarly tested in this rat model. Cyclophosphamide delayed the onset of paralysis, but levamisole enhanced the severity of the EAE.This publication has 41 references indexed in Scilit:
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