The Relationship of pKa and Acute Skin Irritation in Man
- 31 December 1987
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 05 (10) , 660-663
- https://doi.org/10.1023/a:1015931105660
Abstract
The relationship between pKa and skin irritation in man is studied for a homologous series of benzoic acid derivatives, which permeate through human skin at comparable rates (15–88 µg/cm2/hr). Skin irritation and pKa are correlated for pKa ≤ 4. Laser Doppler velocimetric assessment of skin blood flow, color meter readings, erythema, edema, and the primary irritation index are all linearly correlated and related to pKa, erythema at 24 hr appears to be the most sensitive parameter to variation in pKa when pKa ≤ 4.This publication has 6 references indexed in Scilit:
- Ionization Constants by Curve Fitting: Application to the Determination of Partition CoefficientsJournal of Pharmaceutical Sciences, 1984
- [Skin tolerance of topical corticoids as dependent upon the pH value of the emulsions].1983
- The quantitative assessment of topical irritancy and its application to unphysiological pH-valuesInflammation Research, 1982
- The topically irritant substance: Essentials — bio-tests — predictionsInflammation Research, 1981
- Irritant actions of unphysiological pH values. A controlled procedure to test for topical irritancyInflammation Research, 1979
- Preparation of Isolated Sheets of Human Stratum CorneumArchives of Dermatology, 1963