The fractionation of urinary iodine. 2. Metabolites excreted during treatment of carcinoma of the thyroid

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Abstract
In the urine of patients receiving large doses of radioactive iodine for treatment of thyroid carcinoma the amount of iodine in organic combination was proportional to the known uptake of radio-active iodine by the thyroid or neoplastic tissue. Two main compounds in the organic fraction are chromatographically identical with 3:5-di-iodotyrosine and 3:5-di-iodo-4-hydroxyphenyl-lactic acid. Several compounds of unknown structure are also present. It is considered probable that urinary diiodotyrosine is derived from circulating thyroglobulin.