Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential
- 1 December 1986
- journal article
- research article
- Published by Springer Nature in Inflammation
- Vol. 10 (4) , 387-392
- https://doi.org/10.1007/bf00915822
Abstract
Polymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of the pathophysiology of many human diseases. We assessed the effect of fish oil on PMNL inflammatory potential by measuring chemiluminescence and Superoxide production before and after six weeks of daily cod liver oil ingestion by healthy volunteers. Phagocytosing PMNLs demonstrated a 27% decrease in chemiluminescence (P < 0.05) and a 64% decrease in Superoxide production (P < 0.01), following the cod liver oil supplementation. Analysis of PMNL and platelet fatty acids revealed the appearance of eicosapentaenoic acid and a significant decrease in arachidonic acid in both types of cells.This publication has 28 references indexed in Scilit:
- Effect of Dietary Enrichment with Eicosapentaenoic and Docosahexaenoic Acids on in Vitro Neutrophil and Monocyte Leukotriene Generation and Neutrophil FunctionNew England Journal of Medicine, 1985
- Human neutrophil chemotactic and degranulating activities of leukotriene B5 (LTB5) derived from eicosapentaenoic acidBiochemical and Biophysical Research Communications, 1983
- NEUTROPHIL POLYMORPHONUCLEARS, MEDIATORS AND THE PATHOGENESIS OF PSORIASISBritish Journal of Dermatology, 1983
- Polymorphonuclear cell function in rheumatoid arthritis and in Felty's syndrome.Annals of the Rheumatic Diseases, 1981
- Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.Journal of Clinical Investigation, 1980
- Mechanisms of cellular interaction with monosodium urate crystals. igg‐dependent and igg‐independent platelet stimulation by urate crystalsArthritis & Rheumatism, 1978
- Oxygen-Dependent Microbial Killing by PhagocytesNew England Journal of Medicine, 1978
- Leukocyte-platelet interaction. Release of hydrogen peroxide by granulocytes as a modulator of platelet reactions.Journal of Clinical Investigation, 1976
- Biological Defense Mechanisms THE EFFECT OF BACTERIA AND SERUM ON SUPEROXIDE PRODUCTION BY GRANULOCYTESJournal of Clinical Investigation, 1974
- The extinction coefficient of cytochrome cBiochimica et Biophysica Acta, 1962