Capillary Permeability in Cutaneous Tissue

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Abstract
Paaske, W. P. Capillary permeability in cutaneous tissue. Acta physiol. scand. 1976. 98. 492–499. Capillary permeability in cutaneous tissue was determined by the single injection, external counting method. A rabbit abdominal skin preparation was developed. After local vasodilatation, 5 μ1 (400 μCi) 51Cr-EDTA was administered intraarterially by a special bolus injection technique, and the response curve was recorded by external registration. The capillary diffusion capacity (the permeability-surface area product) for 51Cr-EDTA amounted to 3.7 m1/100 g·min at a capillary extraction of 0.59 and a plasma flow of 4.8 m1/100 gemin. The permeability coefficient for 51Cr-EDTA in cutaneous tissue was calculated to 0.9.10-5 cm/s assuming a capillary surface area of 70 cm2/g.