TL-201 SCINTIGRAPHY IN BONE SARCOMA - COMPARISON WITH GA-67 AND TECHNETIUM-MDP IN THE EVALUATION OF CHEMOTHERAPEUTIC RESPONSE

  • 1 May 1990
    • journal article
    • research article
    • Vol. 31  (5) , 567-572
Abstract
This study attempts to characterize thallium-201 (201TI) uptake in patients with bone and soft-tissue sarcoma and to compare these findings with gallium-67 (67Ga) and bone scintigraphy with emphasis on evaluating tumor viability before and after chemotherapy. Thirty-eight patients with surgically-proven sarcomas were evaluated. All patients had gallium and thallium studies. Nineteen patients underwent pre- and post-chemotherapy thallium and evaluation. Seven patients also had technetium-99m-MDP (99mTc-MDP) bone scintigraphy comparisons. Pathologic changes pre and post-chemotherapy were graded on the basis of % tumor necrosis as defined histologically. Scintigraphic comparisons demonstrated a high degree of correlation with 201TI and poor correlation with 99mTc-MDP. Thallium-201 was superior to 99mTc-MDP and 67Ga in predicting tumor resonse to chemotherapy as determined by % tumor necrosis determined histologically. Gallium was superior to Tc-MDP in predicting resonse to chemotherapy. However, both 67Ga and 99mTc-MDP appear to be affected by factors other than tumor activity.