Experimental Infection of Rhesus Monkeys with SIV Isolated from African Green Monkeys
- 1 January 1989
- journal article
- research article
- Published by S. Karger AG in Intervirology
- Vol. 30 (1) , 66-72
- https://doi.org/10.1159/000150126
Abstract
To establish an animal model for AIDS, 6 juvenile rhesus monkeys were infected intravenously with cell-free SIVagmTYO-1, 5, or 7. One animal was infected with SIV of known pathogenicity isolated from a sooty mangabey (SIVsmm). The 2 animals infected with TYO-1, 1 of 2 infected with TYO-7 and the 1 infected with SIVsmm seroconverted within 4–8 weeks after infection and infectious virus could be recovered 8–10 or 44 weeks after infection. Three of the 4 seroconverted monkeys developed a persistent lymphadenopathy 12 weeks after infection. Rhesus monkeys infected with SIVagm could serve as a model to study HIV infection and for vaccine trials.Keywords
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