Akanthomycin, a New Antibiotic Pyridone from the Entomopathogenic Fungus Akanthomyces gracilis
- 5 February 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (5) , 671-673
- https://doi.org/10.1021/ol016737q
Abstract
Organic extracts of the entomopathogenic fungus Akanthomyces gracilis ARS 2910 contained antibiotics active against Staphylococcus aureus. Bioassay-guided fractionation of the CH2Cl2 extract yielded the antibacterial compound akanthomycin as a mixture of atropisomers along with the closely related compounds 8-methylpyridoxatin and cordypyridone C. Akanthomycin was characterized using X-ray crystallography and NMR.Keywords
This publication has 10 references indexed in Scilit:
- Structures of Cordypyridones A−D, Antimalarial N-Hydroxy- and N-Methoxy-2-pyridones from the Insect Pathogenic Fungus Cordyceps nipponicaThe Journal of Organic Chemistry, 2001
- Statistical Investigation into the Structural Complementarity of Natural Products and Synthetic CompoundsAngewandte Chemie International Edition in English, 1999
- The fascination of fungi: Exploring fungal diversityMycologist, 1997
- New Destruxins from the Entomopathogenic Fungus Aschersonia sp.Journal of Natural Products, 1996
- Potential of Fungi in the Discovery of Novel, Low-Molecular Weight PharmaceuticalsBiotechnology (reading, Mass.), 1994
- Entomogenous FungiPublished by Elsevier ,1981
- Cyclosporin A, ein immunsuppressiv wirksamer Peptidmetabolit aus Trichoderma polysporum (LINK ex PERS.) RifaiHelvetica Chimica Acta, 1976
- New techniques in biosynthetic studies using 13C nuclear magnetic resonance spectroscopy. The biosynthesis of tenellin enriched from singly and doubly labelled precursorsJournal of the Chemical Society, Chemical Communications, 1974
- Intramolecular electrostatic stabilization of an SN1 transition stateThe Journal of Organic Chemistry, 1973
- INVESTIGATIONS ON THE GENERA BEAUVERIA VUILL, AND TRITIRACHIUM LIMBERCanadian Journal of Botany, 1954