Studies of Tissue Response to Injections of Enzymes

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Abstract
The presence of proteolytic enzymes in blood has been known for a long time. A variety of methods and agents have been employed to activate these enzymes. Among these, is streptokinase, a bacterial kinase obtained from the hemolytic streptococcus. The subcutaneous "nodules" and significant hexosamine alterations which occurred following the single subcutaneous inoculation of crude streptokinase, resembled those obtained with partially purified streptokinase and with trypsin-(crude and crystalline). Although it is possible that the results obtained with streptokinase were due to the direct conversion of the proteolytic enzyme to its active form, and that changes noted with trypsin were due to the nullification of the inhibitor with the concomitant liberation of the free and active enzyme, it is also very possible that both trypsin and streptokinase give rise to the liberation of a tissue activator, which in turn catalyzes the transformation of the proteolytic enzyme to its active form.

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