IMMUNOGLOBULIN CLASSES IN ANTIBODY RESPONSES IN MICE .I. ANALYSIS BY BIOLOGICAL PROPERTIES

  • 1 January 1968
    • journal article
    • research article
    • Vol. 14  (5) , 725-+
Abstract
The formation of different immunoglobulin classes of mouse antibodies to dinitrophenol (DNP) was qualitatively determined by biological assays which discriminate between some immunoglobulin classes. Antibody responses to 2 other antigens were compared in 5 mouse strains. Mice of 5 different strains immunized with DNP-hemocyanin (DNP-Hcy) in complete Freund''s adjuvant made both [gamma]G1 and [gamma]G2a antibodies. The amounts of antibody are less in DBA and C57 mice and at 80 days after primary immunization a 2-mercaptoethanol sensitive (2MES) antibody is still present in these strains (but not in A, AKR and C3H). When DNP-Hcy is given in Al(OH)3, very little [gamma] G2a is produced in any strain, although [gamma]G1 antibodies are produced as in mice given DNP-Hcy in complete Freund''s adjuvant. Possible interpretations of these observations are discussed.

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