The effect of indomethacin on the local cerebral blood flow increase induced by somato‐sensory stimulation
- 1 November 1984
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 122 (3) , 269-274
- https://doi.org/10.1111/j.1748-1716.1984.tb07510.x
Abstract
The local cerebral blood flow in cerebral cortical and subcortical regions of the rat brain was studied with the14C‐iodoantipyrine autoradiographic technique at rest and during strong non‐noxious stimulation of the nose. Patterns of local blood flow changes evoked by stimulation with and without pretreatment of indomethacin, a potent cyclooxygenase inhibitor were determined. Stimulation produced a marked heterogeneous enhancement of CBF. Indomethacin did not prevent this effect although the absolute flow levels were considerably lower in indomethacin‐treated animals. Indomethacin was especially effective in reducing the cerebral cortical blood flow response to stimulation whereas the subcortical response was much less affected.Keywords
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