Six‐Month Effects of a Sanguinarine Dentifrice on Plaque and Gingivitis

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Abstract
A six‐month, double‐blind clinical trial was conducted to determine the effectiveness of a sanguinarine‐containing dentifrice in reducing plaque and gingival inflammation. One hundred twenty adult volunteers were randomly assigned to a control or experimental group. The test dentifrice contained 750 mcg/g of sanguinaria extract. A dentifrice of similar composition without sanguinarine was used as the placebo. Plaque and gingival inflammation scores were recorded for four surfaces on each of 12 index teeth at baseline, one‐, three, and six‐months. Matched pair t‐test analyses showed no significant differences between experimental and control groups for mean six‐month changes in plaque and gingival inflammation scores in analyses using all 48 sites per subject or in analyses of only the 24 interproximal sites. No long‐term reduction was demonstrated in plaque or gingival inflammation with the use of a sanguinarine‐containing dentifrice.